High-Density Lipoproteins and Serum Amyloid A (SAA)
نویسندگان
چکیده
منابع مشابه
Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.
Inflammation-related (AA) amyloidosis is a severe clinical disorder characterized by the systemic deposition of the acute-phase reactant serum amyloid A (SAA). SAA is normally associated with the high-density lipoprotein (HDL) fraction in plasma, but under yet unclear circumstances, the apolipoprotein is converted into amyloid fibrils. AA amyloid and heparan sulfate (HS) display an intimate rel...
متن کاملSerum amyloid A: high-density lipoproteins interaction and cardiovascular risk.
AIMS High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular outcome remains unknown. METHODS AND RESULTS We examined the association o...
متن کاملHuman serum amyloid A (SAA)
Serum amyloid A apol ipoprote in family consists of three members that in human beings are coded by different genes: SAA1, SAA2, and SAA4 (reviewed in 1-3). SAA1 and SAA2 are so-called acute phase isoforms. Their expression is increased in response to inflammation. SAA4 is a constitutive isoform, the expression of which does not change during an acute-phase response. In addition, one more relat...
متن کاملEffects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.
The acute phase reactant serum amyloid A protein (SAA) circulates in plasma as a constituent of high density lipoproteins (HDL). Advantage has been taken of the induction of SAA in human subjects with myocardial infarction to study the effect of SAA on the physical and chemical properties of HDL. HDL were isolated by sequential ultracentrifugation and assayed for chemical composition. Apolipopr...
متن کاملStudies on Human Serum High Density Lipoproteins
Human serum apolipoprotein A-I (ape-A-I), the major protein component of the human serum high density lipoproteins, was studied in aqueous solutions of differing ionic strengths and pH by the techniques of sedimentation equilibrium ultracentrifugation and frontal analysis gel chromatography. The ultracentrifugal studies indicate that apo-A-I is a self-associating system that is dependent upon p...
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ژورنال
عنوان ژورنال: Current Atherosclerosis Reports
سال: 2021
ISSN: 1523-3804,1534-6242
DOI: 10.1007/s11883-020-00901-4